(-)-chicoric acid, (-)-L-chicoric acid, (2R,3R)-2,3-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl)oxy)-butanedioic acid, chicoric acid, cichoric acid, dicaffeoyltartaric acid, L-chicoric acid
| Name | Chicoric acid | ||
| PubChem CID | 5281764 | ||
| Molecular Weight | 474.4g/mol | ||
| Synonyms |
(-)-chicoric acid, (-)-L-chicoric acid, (2R,3R)-2,3-bis(((2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl)oxy)-butanedioic acid, chicoric acid, cichoric acid, dicaffeoyltartaric acid, L-chicoric acid |
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| Formula | C₂₂H₁₈O₁₂ | ||
| SMILES | C1=CC(=C(C=C1C=CC(=O)OC(C(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)C(=O)O)O)O | ||
| InChI | 1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1 | ||
| InChIKey | YDDGKXBLOXEEMN-IABMMNSOSA-N | ||
| CAS Number | 70831-56-0 | ||
| ChEMBL ID | CHEMBL282731 | ||
| ChEBI ID | CHEBI:3594 | ||
| KEGG ID | C10437 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZiHuaDiDing | ||
| Use Part | Whole Grass | ||
| Habitat | China | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Heart, Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Violaceae
-->Genus: Viola
-->Species: Viola yedoensis
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| Chineses Pinyin | JuJu | ||
| Use Part | Aerial Parts, Root | ||
| Habitat | BeiJing, HeiLongJiang, LiaoNing, ShanXi, Shaanxi, XinJiang, JiangXi | ||
| Flavor | Mildly bitter, Salty | ||
| Meridian Tropism | Liver, Gallbladder, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Cichorium
-->Species: Cichorium glandulosum
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| Chineses Pinyin | MaoYeFanLiZhi | ||
| Use Part | Fruit, Bark, Leaf, Flower, Root | ||
| Habitat | YunNan, GuangDong | ||
| Chineses Pinyin | PuGongYing | ||
| Use Part | Aerial parts | ||
| Habitat | China | ||
| Flavor | Bitter; Sweet | ||
| Meridian Tropism | Liver; Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Taraxacum
-->Species: Taraxacum mongolicum
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| Pair Name | Chicoric acid, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Down-regulation | Expression | MAP2K7 | hsa5609 | |
| Up-regulation | Activity | MAPK8 | hsa5599 | |
| Down-regulation | Expression | TIPRL | hsa261726 | |
| In Vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 |
| Result | Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy. | |||
